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YM155 shows 80% TGI at a dose of 5 mg/kg in PC-3 orthotopic xenografts[1]
Odanacatib also shows weak inhibition of the processing of the MHC II invariant chain protein Iip10 in mouse splenocytes compared to LHVS (minimum inhibitory concentration 1-10 μM versus 0
Chemical Name: (S)-N-(4-((2S
Formula: C19H19N3O2
PubMed PMID: 22444253
Triptonide - CAS# 38647-11-9 60313 YM155 shows 80% TGI atTriptonide, CAS No. 38647 11 9, is a Wnt catenin inhibitor. Triptonide can effectively inhibit canonical Wnt catenin signaling by targeting the downstream C terminal transcription domain of catenin or a nuclear component associated with catenin. It also effectively induced apoptosis of Wnt dependent cancer cells, supporting the therapeutic potential of triptonide. Product information CAS Number: 38647 11 9 Molecular Weight: 358. 39 Formula: C20H22O6