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InChi: InChI=1S/C15H18O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8
2014 Jun 26
Lenalidomide and pomalidomide inhibits autoubiquitination of CRBN in HEK293 T cells expressing thalidomide-binding competent wild-type CRBN
Chemical Name: 6-Benzyl-3-(3-(thiazol-5-ylmethoxy)phenyl)-3
NCI-H23 and NCI-H358 cells) with DC50s between 0
Z-VAD(OMe)-FMK 539 HCl InChi: InChI=1S/C15H18O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8Z VAD FMK is a cell permeable, irreversible pan caspase inhibitor. Z VAD FMK inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0. 0015 5. 8 mM). Z VAD(OMe) FMK is an ubiquitin carboxy terminal hydrolase L1 (UCHL1) inhibitor. Z VAD(OMe) FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1. Product information CAS Number: 187389 52 2 Molecular Weight: 467. 49 Formula: C22H30FN3O7 Synonym: Z VAD(OMe) FMK
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