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In rat pharmacokinetics studies
InChi: InChI=1S/C20H27N3O2/c1-13-12-22(16-3-2-4-16)9-10-23(13)20(25)18-11-17(18)14-5-7-15(8-6-14)19(21)24/h5-8
Smiles: CC(C)(C)[Si](C)(C)OC[C@H]1O[C@H](C[C@@H]1O)N1C=NC2C1=NC=NC=2NC(=O)C1C=CC=CC=1
elevated global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents
Smiles: BrCCOCCOCCOCCOCCOCCOCCOCC1C=CC=CC=1
Tyk2-IN-5 ino pyrazole In rat pharmacokinetics studiesTyk2 IN 5 (compound 6) is a highly potent, selective and orally active Tyk2 inhibitor and targets the JH2 domain, with a Ki of 0. 086 nM for Tyk2 JH2 and an IC50 of 25 nM for IFN. Highly effective in inhibiting IFN production in a rat pharmacodynamics model and fully efficacious in a rat adjuvant arthritis model. Product information CAS Number: 1797432 62 2 Molecular Weight: 434. 43 Formula: C21H19FN8O2 Chemical Name: N [(1R,2S) 2 fluorocyclopropyl] 8